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Clear skies. Low 48F. Winds light and variable.
Updated: September 11, 2026 @ 8:57 pm

The BioAssemblyBot, or BAB for short, is a robotic platform with a multi-access arm. An instrument tells BAB what to do to build specific tissue.
Jay Hoying
Jay Hoying

The BioAssemblyBot, or BAB for short, is a robotic platform with a multi-access arm. An instrument tells BAB what to do to build specific tissue.
The BioAssemblyBot, or BAB for short, is a robotic platform with a multi-access arm. An instrument tells BAB what to do to build specific tissue.
Jay Hoying
Jay Hoying
Jay Hoying can’t remember a time he didn’t want to be a scientist. He started out watching “Nova” on PBS when he was about 8 years old. He pursued his passion through elementary, middle and high school, with one memorable moment standing out: in elementary school, his science teacher was sick and asked him to take over the class.
“I’m not sure how well I did,” Hoying said, thinking back.
He did well enough to go into the scientific field, and to focus on living tissue and regenerative medicine. He’s at the forefront of a growing discipline, tissue therapeutics.
At this year’s Wicked STEM Expo, he will speak on “Rebuilding the Body: Advances in Tissue Therapeutics.”
Hoying is the chief research scientist for Advanced Life Solutions in their Life Sciences division (ALSLS). The company’s headquarters is in Louisville, Kentucky, and the Research Division works out of Manchester’s Millyard.
Life Sciences, he said, is a subsidiary of the company dedicated to creating tech platforms to facilitate therapeutic tissue repair.
“The concept of tissue therapy is relatively new,” he said. “So many different disciplines go into the process of building tissues to repair diseases.”
The company’s to-do list includes using science and tech to identify molecules causing a disease, discovering new drug pathways, and testing of drugs without using animals for the research.
Advanced Solution’s core technical platform is the BioAssemblyBot, or BAB for short, according to Hoying.
“BAB is a robotic platform with a multi-access arm, and an instrument tells BAB what to do to build specific tissue,” he said.
According to Advanced Solution’s website, BAB offers a way to readily manufacture, replicate and scale in size advanced 3D tissue models. With BAB, design, simulate, fabricate and collaborate on advanced 3D tissue models.
Hoying came to tissue studies through a circuitous route. He studied general biology as an undergraduate, got his master’s degree in plant physiology and attended medical school at Thomas Jefferson University in Philadelphia.
He conducted laboratory studies on blood vessels and remembered being fascinated by “how the smallest blood vessels grow, especially in tissue repair.”
After earning a doctorate degree in physiology from the University of Arizona, and postdoctoral work at the University of Connecticut, he performed research work at the Universities of Arizona and Louisville, working alongside clinicians, engineers and mathematicians, all focused on the question, “Can we cure disease with the replacement of tissue?”
He met Michael Galway, president and CEO of Advanced Life Solutions Inc., and came to work for the firm.
Hoying, 64, has seen many advances in medical science over his lifetime. He remembers when the first bone marrow transplants were achieved, and said, “Now it’s routine.”
He’s seen the development of corneal transplants and the grafting of tissue from one donor to another.
Rebuilding of tissue has been “online” for 10 to 15 years, he said, adding, “Hundreds of clinical trials are on the market right now.”
Hoying and his team are involved in a project with the Department of Veterans Affairs involving rebuilding bones in the jaw.
“We’re working with an innovative group out of Seattle, with Dr. Beth Ripley of the Puget Sound VA,” he said.
The project, which started in 2018, involves finding a way to rebuild the lower jaw after removing a tumor, Hoying said. The solution so far involves using a small bone from the calf in the lower leg to replace the jawbone.
“Getting a calf bone to look like a jawbone is — challenging,” he said.
The project is also challenging because the researchers need the replacement piece to be living.
“If we use plastic, metal or ceramic matter, it could be subject to infection,” he said.
“From a science perspective, it’s a fascinating challenge,” Hoying said. “From a patient perspective, the replacement improves their quality of life and also their survival rate.”
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